NF-kappa B genes have a major role in Inflammatory Breast Cancer
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چکیده
منابع مشابه
Prognostic and therapeutic role of nuclear factor-kappa B (NF-kappaB) in breast cancer.
Nuclear Factor- kappa B (NF-kappaB) is an essential transcription factor that not only modulates cellular responses to stress but also plays a pivotal role in inflammation, immunity, cell cycle growth and survival. NF-kappaB-regulated genes have been documented to be involved in cellular proliferation and invasion along with tumour related angiogenesis and lymphangiogenesis. Dysregulation of NF...
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The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing...
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NF-κB is a pleiotropic protein whose nucleo-cytoplasmic trafficking is tightly regulated by multiple negative feedback loops embedded in the NF-κB signaling network and contributes to diverse gene expression profiles important in immune cell differentiation, cell apoptosis, and innate immunity. The intracellular signaling processes and their control mechanisms, however, are susceptible to both ...
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Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in various types of cultured neurons against glutamate excitotoxicity and induced-apoptosis. Some of the effects of PEDF reflect specific changes in gene expression, mediated via activation of the transcription factor NF-kappa B in neurons. To investigate whether PEDF also modulates...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2008
ISSN: 1471-2407
DOI: 10.1186/1471-2407-8-41